| LeiriaUnião Desportiva de Leiria |
5-0 |
CastellónClub Deportivo Castellón |
| União Desportiva de Leiria won 5-1 on aggregate |
| LiverpoolLiverpool |
1-0 |
Géants AthoisRoyal Géants Athois |
| Liverpool won 2-0 on aggregate |
| Glasgow RangersGlasgow Rangers |
3-2 |
AlbinoLeffeU.C. AlbinoLeffe |
| U.C. AlbinoLeffe won 4-3 on aggregate |
| OberhausenRot-Weiß Oberhausen |
1-0 |
Foresta SuceavaACS Foresta Suceava |
| 2-2 on aggregate, Rot-Weiß Oberhausen won on away goals |
| BirminghamBirmingham City |
5-2 |
FreamundeSport Clube Freamunde |
| Birmingham City won 6-5 on aggregate |
| BordeauxFC Girondins de Bordeaux |
1-0 |
Le HavreLe Havre Athletic Club |
| Le Havre Athletic Club won 2-1 on aggregate |
| WrexhamWrexham |
1-3 |
BeauvaisAS Beauvais Oise |
| AS Beauvais Oise won 6-1 on aggregate |
| MontroseMontrose |
0-0 |
LeverkusenBayer 04 Leverkusen |
| 1-1 on aggregate, Montrose won on away goals |
| SpartaSparta Rotterdam |
1-1 |
CórdobaCórdoba |
| Córdoba won 4-1 on aggregate |
| Atlético MadridAtlético Madrid |
1-3 |
AachenTSV Alemannia Aachen |
| TSV Alemannia Aachen won 5-2 on aggregate |
| CarregadoAssociação Desportiva do Carregado |
0-1 |
BielefeldDSC Arminia Bielefeld |
| DSC Arminia Bielefeld won 2-0 on aggregate |
| AjaxAFC Ajax |
1-6 |
AberdeenAberdeen |
| Aberdeen won 7-3 on aggregate |
| JenaFC Carl Zeiss Jena |
3-2 |
MontpellierMontpellier Hérault SC |
| 4-4 on aggregate, Montpellier Hérault SC won on away goals |
| Vitória Sport ClubVitória Sport Club |
1-0 |
Real OviedoReal Oviedo |
| 1-1 on aggregate, Vitória Sport Club won 2-1 after extra time |
| CosenzaCosenza Calcio |
2-1 |
OxfordOxford United |
| 3-3 on aggregate, 4-4 after extra time, Oxford United won 6-5 on penalties |
| LilleLille OSC |
2-3 |
Notts CountyNotts County |
| Notts County won 3-2 on aggregate |
| RegginaReggina |
1-0 |
AvesClube Desportivo das Aves |
| Reggina won 1-0 on aggregate |
| Rio AveRio Ave Futebol Clube |
2-3 |
HérculesHércules |
| Hércules won 5-3 on aggregate |
| OlimpiaACS Olimpia 2010 Râmnicu Sărat |
3-2 |
FeirenseClube Desportivo Feirense |
| ACS Olimpia 2010 Râmnicu Sărat won 4-3 on aggregate |
| AueFC Erzgebirge Aue |
4-1 |
PortoFutebol Clube do Porto |
| FC Erzgebirge Aue won 4-1 on aggregate |
| WalsallWalsall |
1-0 |
DeportivoDeportivo de La Coruña |
| Walsall won 3-0 on aggregate |
| Den BoschFC Den Bosch |
3-1 |
HeistKSK Heist |
| FC Den Bosch won 5-2 on aggregate |
| MilanA.C. Milan |
3-1 |
SC CambuurSC Cambuur-Leeuwarden |
| A.C. Milan won 4-2 on aggregate |
| CFR ClujFC CFR 1907 Cluj |
0-5 |
ASU PoliACS ASU Politehnica Timişoara |
| ACS ASU Politehnica Timişoara won 6-1 on aggregate |
| ClermontClermont Foot 63 |
2-1 |
Go AheadGo Ahead Eagles |
| Clermont Foot 63 won 3-2 on aggregate |
| Astra GiurgiuAFC Astra Giurgiu |
0-2 |
HibernianHibernian |
| Hibernian won 2-1 on aggregate |
| BrechinBrechin City |
0-3 |
Dunărea CălăraşiAFC Dunărea 2005 Călăraşi |
| AFC Dunărea 2005 Călăraşi won 8-1 on aggregate |
| Diegem-SportKoninklijke Diegem Sport |
4-1 |
HeartsHeart Of Midlothian |
| Koninklijke Diegem Sport won 6-3 on aggregate |
| BarcelonaF.C. Barcelona |
1-2 |
TrapaniTrapani Calcio |
| Trapani Calcio won 3-2 on aggregate |
| CataniaCatania |
2-0 |
ParmaParma |
| Catania won 4-3 on aggregate |
| Almere CityAlmere City FC |
0-1 |
GroningenFC Groningen |
| FC Groningen won 4-0 on aggregate |
| Patro EisdenK. Patro Eisden Maasmechelen |
6-0 |
MéridaMérida |
| K. Patro Eisden Maasmechelen won 7-1 on aggregate |